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The objective of this subject is to familiarise students with model systems for research in biomedicine; bacteria: beneficial and harmful bacteria; viruses and infectious molecules; fungal pathogens and the role of fungi in medicine; evolution of primates and humans. The modern concepts of genetics, human evolution and model organisms used in biomedicine research.
Topics include the genetic consequence of meiosis; inheritance; chromosomes, genes/alleles, dominance relationships, autosomal/sex-linked inheritance; one locus, blood groups, pedigree analysis, examples of human genetic disease; more than one locus, gene interaction, linkage, multifactorial/quantitative inheritance, heritability; DNA structure and function, replication, transcription, translation, mutation; genes and development; tools used for molecular genetic analysis: restriction enzymes, PCR, gel electrophoresis, aims of the Human Genome Project; recombinant DNA technology; genes in populations; human diversity, polymorphisms, selection, the theory of evolution; species; biodiversity and genetic resources.
Intended learning outcomes
At the completion of this subject, students should be able to
- understand the various transmission and invasion strategies of parasites.
- understand the taxa of parasites and the importance of sexual and asexual reproduction to them.
- understand how natural selection works and resistance evolves.
- understand the evolutionary history of humans
- describe the basic mechanisms of inheritance, including the relationship between phenotype and genotype, transmission genetics, recombination and multifactorial inheritance
- explain the structure of DNA, its replication and the molecular basis of gene expression,transcription, translation, the genetic code and mutation.
- describe tools used in molecular genetic analysis and aims of the Human Genome Project
- describe the nature of genetic variation in populations, natural selection, microevolution, reproductive isolation and speciation
- explain the evidence for the evolution of life including molecular, fossil and phylogenic data with emphasis on primate evolution
- appreciate the biodiversity of life including the importance of bacteria, viruses and fungi in biomedical science
At the completion of this subject students should be able to:
- plan effective work schedules to be prepared for tutorials, practical classes and examinations.
- be familiar with electronic forms of communication and be discerning in the use of the web for seeking information.
- integrate the computer software packages into the course to assist learning.
- be able to complete basic manipulations with laboratory equipment, for example the microscope and gel electrophoresis.
- develop skills in recording observations, analysis and interpretation of data
- develop basis skills in statistical analysis of genetic data.
- access basic information from the library both electronically and in a traditional way.
- begin to develop skills in working collaboratively with other students in a practical class.
Last updated: 9 February 2022