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Systems Biology (BMEN90027)
Graduate courseworkPoints: 12.5Not available in 2019
Overview
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AIMS:
This subject introduces mathematical and computational modelling, simulation and analysis of biological systems. The emphasis is on developing models, with examples, using MATLAB.
INDICATIVE CONTENT:
Topics include:
Modelling biochemical reactions. Law of mass action. Enzymes and regulation of enzyme reactions. Thermodynamics of reversible biochemical reactions. Cellular homeostasis. Application of ordinary differential equations to these problems.
Modelling large reaction networks. Flux balance analysis and constraint-based methods. Genome-scale models. Regulation of gene expression. Gene regulatory networks in systems and synthetic biology. Network inference and statistical modelling of –omic data. Knowledge-based modelling in systems biology.
Intended learning outcomes
INTENDED LEARNING OUTCOMES (ILOs)
Having completed this unit the student should be able to:
1 - describe the role for mathematical and computational modelling of biological systems;
2 - use the law of mass action to develop ODE models for biochemical reactions;
3 - develop and analyse models for enzyme catalysed reactions in cellular bioengineering and synthetic biology;
4 - develop and analyse ODE and PDE models in molecular and cellular physiology;
5 - describe the premise of systems biology;
6 - develop and analyse large-scale network models for biosystems and synthetic biology;
7- describe the role of knowledge-based modelling in systems biology;
8 - describe the measurement technologies and sources of data underlying systems biology, data repositories and modelling approaches.
Generic skills
On completion of this subject students should have developed the following generic skills:
- Ability to apply knowledge of science and engineering fundamentals.
- Ability to communicate effectively, with the engineering team and with the community at large.
- Capacity for lifelong learning and professional development.
- Profound respect for truth and intellectual integrity, and for the ethics of scholarship.
Last updated: 3 November 2022
Eligibility and requirements
Prerequisites
Either
Code | Name | Teaching period | Credit Points |
---|---|---|---|
MAST20029 | Engineering Mathematics |
Semester 1 (On Campus - Parkville)
Semester 2 (On Campus - Parkville)
Summer Term (On Campus - Parkville)
|
12.5 |
OR
Both of the following subjects
Code | Name | Teaching period | Credit Points |
---|---|---|---|
MAST20009 | Vector Calculus |
Semester 2 (On Campus - Parkville)
Semester 1 (On Campus - Parkville)
|
12.5 |
MAST20030 | Differential Equations | Semester 2 (On Campus - Parkville) |
12.5 |
OR
Equivalent Mathematics subject
Corequisites
None
Non-allowed subjects
None
Inherent requirements (core participation requirements)
The University of Melbourne is committed to providing students with reasonable adjustments to assessment and participation under the Disability Standards for Education (2005), and the Assessment and Results Policy (MPF1326). Students are expected to meet the core participation requirements for their course. These can be viewed under Entry and Participation Requirements for the course outlines in the Handbook.
Further details on how to seek academic adjustments can be found on the Student Equity and Disability Support website: http://services.unimelb.edu.au/student-equity/home
Last updated: 3 November 2022
Assessment
Additional details
- Participation in up to six workshops in Weeks 2 to 12, of which 4 are assessed with a written assignment of approximately 500 words, requiring 13-15 hours of work including preparation (10% each)
- One mid-semester test of 1 hour duration in Week 7
- One written 2-hour end-of-semester examination (50%).
Hurdle requirement: The examination must be passed to successfully complete the subject.
Intended Learning Outcomes (ILOs) 1 to 8 are assessed in the final written examination, assignments and workshop reports. ILOs 1 to 4 are also assessed in the mid-semester test.
Last updated: 3 November 2022
Dates & times
Not available in 2019
Time commitment details
200 hours
Last updated: 3 November 2022
Further information
- Texts
Prescribed texts
- Related Handbook entries
This subject contributes to the following:
Type Name Specialisation (formal) Biomedical - Available through the Community Access Program
About the Community Access Program (CAP)
This subject is available through the Community Access Program (also called Single Subject Studies) which allows you to enrol in single subjects offered by the University of Melbourne, without the commitment required to complete a whole degree.
Entry requirements including prerequisites may apply. Please refer to the CAP applications page for further information.
Additional information for this subject
Subject coordinator approval required
- Available to Study Abroad and/or Study Exchange Students
This subject is available to students studying at the University from eligible overseas institutions on exchange and study abroad. Students are required to satisfy any listed requirements, such as pre- and co-requisites, for enrolment in the subject.
Last updated: 3 November 2022