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Downstream Bioprocessing (CHEN90035)
Graduate courseworkPoints: 12.5On Campus (Parkville)
To learn more, visit 2023 Course and subject delivery.
About this subject
- Overview
- Eligibility and requirements
- Assessment
- Dates and times
- Further information
- Timetable(opens in new window)
Contact information
Summer Term
Professor Ray Dagastine
Contact: rrd@unimelb.edu.au
Overview
Availability | Summer Term |
---|---|
Fees | Look up fees |
AIMS
The goal of the course is to develop familiarity with the requirements and methods of downstream processing, i.e., separation, purification and formulation, in biotechnological applications, particularly for biopharmaceutical production. The course will introduce general principles of downstream processing but most of the semester will be devoted to the treatment of the most important unit operations employed in downstream processing. As is typical for chemical engineering courses, this one will include elements of both analysis and synthesis (i.e., design). Although the modern industry depended extensively on empiricism over much of its first few decades, there is increasing interest in and use of a deeper fundamental understanding of individual unit operations, including use of detailed computer simulations. The emphasis in the course will be on such a fundamental treatment of the various operations that we will encounter and will include use of computational models. References to relevant published research articles will also be provided.
INDICATIVE CONTENT
Biological products and impurities. Bioseparations strategies; Analytical methods; Cell lysis. Formation of solids: Flocculation, precipitation; Removal of solids: Centrifugation. Membrane processes: Filtration principles. Modes and of Optimisation of filtration. Chromatography: Overview and principles, operating modes, applications of chromatography for different biopharmaceutical products; Modelling of chromatographic behaviour; Viral clearance. Crystallisation; Drying; Additional topics in formulation.
Intended learning outcomes
On completion of this subject the student is expected to:
- Develop a familiarity with the requirements and methods of downstream processing to be able to differentiate the need for separation, purification or formulation operations in biotechnological applications.
- Students will be able to analyse downstream processing or separation requirements to design appropriate unit operations for the specific applications or processes.
- At the end of this subject students will be able to demonstrate the ability to use computational models to evaluate and design various unit operations in downstream processing.
Generic skills
- Capacity for independent thought
- Awareness of advanced technologies in the discipline
- Ability to apply knowledge of basic science and engineering fundamentals
- Ability to undertake problem identification, formulation and solution
- Ability to utilise a systems approach to design and operational performance
Last updated: 31 January 2024
Eligibility and requirements
Prerequisites
One of
Code | Name | Teaching period | Credit Points |
---|---|---|---|
CHEN30016 | Momentum, Mass and Heat Transfer | Semester 2 (On Campus - Parkville) |
12.5 |
OR
One of
Code | Name | Teaching period | Credit Points |
---|---|---|---|
CHEN30005 | Heat and Mass Transport Processes | No longer available |
(Prior to 2023)
OR
Admission into the MC-CHEMENG Master of Chemical Engineering, Chemical specialisation (formal) in the MC-ENG Master of Engineering
Corequisites
None
Non-allowed subjects
None
Inherent requirements (core participation requirements)
The University of Melbourne is committed to providing students with reasonable adjustments to assessment and participation under the Disability Standards for Education (2005), and the Assessment and Results Policy (MPF1326). Students are expected to meet the core participation requirements for their course. These can be viewed under Entry and Participation Requirements for the course outlines in the Handbook.
Further details on how to seek academic adjustments can be found on the Student Equity and Disability Support website: http://services.unimelb.edu.au/student-equity/home
Last updated: 31 January 2024
Assessment
Description | Timing | Percentage |
---|---|---|
Continuous assessment comprising regular homework problem sets (2 per week, for 4 weeks = 8 problem sets).
| From Week 1 to Week 4 | 10% |
One 1-hour mid-semester examination in week 2.
| Week 2 | 35% |
A computational project that applies the use of Chromatography Analysis and Design Toolkit (CADET) package.
| Week 3 | 20% |
One 1-hour end-of-semester examination in week 4.
| Week 4 | 35% |
Last updated: 31 January 2024
Dates & times
- Summer Term
Principal coordinator Ray Dagastine Mode of delivery On Campus (Parkville) Contact hours 18x 2-hour lectures, 1x 2-hour Computer Practical workshops. Total time commitment 200 hours Teaching period 3 January 2023 to 27 January 2023 Last self-enrol date 9 January 2023 Census date 13 January 2023 Last date to withdraw without fail 20 January 2023 Assessment period ends 3 February 2023 Summer Term contact information
Professor Ray Dagastine
Contact: rrd@unimelb.edu.au
Time commitment details
200 hours
What do these dates mean
Visit this webpage to find out about these key dates, including how they impact on:
- Your tuition fees, academic transcript and statements.
- And for Commonwealth Supported students, your:
- Student Learning Entitlement. This applies to all students enrolled in a Commonwealth Supported Place (CSP).
Subjects withdrawn after the census date (including up to the ‘last day to withdraw without fail’) count toward the Student Learning Entitlement.
Last updated: 31 January 2024
Further information
- Texts
Prescribed texts
Chemical Product Development (1):
None
Biochemical Engineering (2):
M. Shuler and F. Kargi, Bioprocess Engineering, Second edition
The Literature and Culture of Australia (3):
Robert Hughes, The Fatal Shore: The Epic of Australia’s Founding. 1987
Nicholas Jose, ed. The Literature of Australia: An Anthology. 2009
Peter Carey, True History of the Kelly Gang: A Novel. 2000
Jill Ker Conway, The Road from Coorain. 1989
Doris Pilkington, Follow the Rabbit-Proof Fence. 1996
- Related Handbook entries
This subject contributes to the following:
Type Name Course Master of Chemical Engineering Specialisation (formal) Biochemical Specialisation (formal) Chemical Specialisation (formal) Chemical with Business - Available through the Community Access Program
About the Community Access Program (CAP)
This subject is available through the Community Access Program (also called Single Subject Studies) which allows you to enrol in single subjects offered by the University of Melbourne, without the commitment required to complete a whole degree.
Entry requirements including prerequisites may apply. Please refer to the CAP applications page for further information.
Additional information for this subject
Subject coordinator approval required
- Available to Study Abroad and/or Study Exchange Students
This subject is available to students studying at the University from eligible overseas institutions on exchange and study abroad. Students are required to satisfy any listed requirements, such as pre- and co-requisites, for enrolment in the subject.
Last updated: 31 January 2024