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Chemical Structure Determination (CHEM90066)

Graduate courseworkPoints: 6.25Not available in 2026

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Overview

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This subject provides in depth training in the technique of X-ray crystallography for the determination of chemical and macromolecular structures. Students will be exposed to the theory that underpins this technique, its practical application and the interpretation and validation of its results. Students will apply current software packages to real data to determine the structures of chemical complexes and proteins. Cutting-edge techniques, particularly those accessible through the Australian Synchrotron that provide complementary structural information will also be discussed.

Intended learning outcomes

Upon completion of this subject, students should be able to:

  • understand the principles of X-ray diffraction as applied to molecular structure determination;
  • apply the technique of X-ray crystallography to analyse experimental data to determine the structures of chemical complexes and proteins;
  • critically analyse crystal structures reported in peer reviewed literature.

Generic skills

On completion of this subject, students should have developed the following generic skills:

  • Advanced problem-solving and critical thinking skills
  • An ability to evaluate the professional literature
  • An understanding of the changing knowledge base
  • A capacity to apply concepts developed in one area to a different context

Last updated: 6 November 2025