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This subject investigates the molecular mechanisms by which cells regulate their replication, function and metabolism, i.e. the essential properties of living organisms. The focus of the subject is the examination of current or classic research that exemplifies these topics.
Subject content focuses on modern research techniques in biochemistry and molecular cell biology. Topics include: the regulation of protein folding and misfolding, gene expression regulation, the transduction of cellular signals, cytoskeletal remodelling and protein trafficking, and the regulation of cellular metabolism. These elegant biochemical processes are fundamental to human existence. This subject is designed to complement and extend both BCMB20002 and BCMB20005.
Intended learning outcomes
By the end of the subject the student should understand:
- the structures of cells, proteins, membranes, DNA and chromatin, and the importance of these structures in regulation of the cell.
- the way that the expression of genes is controlled and how this impacts cell structure and function
- the importance of protein folding and the mechanisms by which this is controlled
- the regulation of cellular processes within and external to cells and communicated by signal transduction molecules.
- the metabolic mechanisms which cells use to extract, convert and store biochemical energy.
- the transport of molecules into, out of, and throughout the cell, and the importance of the cytoskeleton in these processes.
- how the scientific literature represents the analysis of the above topics.
- how to interpret research data in these topic areas.
On completion of this subject, students should have developed the following generic skills:
- have an in-depth understanding of the biochemical regulation of cell function
- understand the principles of sound project and experimental design, including data analysis
- be critical thinkers
- apply analytical skills to problem solving
Last updated: 8 November 2019