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This subject will describe the wide range of structures, functions and interactions of proteins and their importance in biological processes, biomedicine and biotechnology. Emphasis will be on the three-dimensional structure of proteins and their interactions with peptides, proteins, lipids, nucleic acids and other physiologically important molecules. We will describe experimental and computational techniques and how they help in determining and predicting protein structure and function and aid in the development of new drugs. The subject matter addresses the general properties of protein structure; the major classes and topologies of proteins; evolution of sequence, structure and function; protein synthesis, folding, misfolding, targeting and trafficking; bioinformatics analysis of protein sequence and structure; binding of small molecules to proteins and drug design; protein-protein interactions; effects of mutations on tertiary structure, protein stability and biological functions; enzyme reaction kinetics and mechanisms. This subject is required for completion of a major in Biochemistry and Molecular Biology.
Intended learning outcomes
By the end of the subject the student should be able to:
- Describe the molecular basis of the evolution of protein sequence and structure.
- Explain the theory behind and practical considerations of experimental techniques used to study protein structure and function.
- Devise experiments to analyse protein structure and function using the techniques studied.
- Perform computational analysis of protein sequence and structure using bioinformatics and molecular graphics tools.
- Critically analyse of the current scientific literature on protein structure and function.
On completion of this subject, students should have developed the following generic skills:
- the ability to interpret scientific literature and interpret data from electronic databases.
- the capacity to integrate knowledge across disciplines.
- the ability to comprehend a question, evaluate the relevant information and communicate an answer.
Last updated: 23 January 2021