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  3. Design of Randomised Controlled Trials

Design of Randomised Controlled Trials (POPH90119)

Graduate courseworkPoints: 12.5Online

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Year of offer2019
Subject levelGraduate coursework
Subject codePOPH90119
Semester 2 - Online
FeesSubject EFTSL, Level, Discipline & Census Date

Topics include: ethical considerations; principles and methods of randomisation in controlled trials; treatment allocation, blocking, stratification and allocation concealment; parallel, factorial and crossover designs including n-of-1 studies; practical issues in sample size determination; intention-to-treat principle; phase I dose finding studies; phase II safety and efficacy studies; interim analysis and early stopping ; multiple outcomes/endpoints, including surrogate outcomes, multiple tests and subgroup analyses, including adjustment of significance levels and P-values; missing data; reporting trial results and use of the CONSORT statement.

Intended learning outcomes

To enable students to understand and apply the principles of design and analysis of experiments, with a particular focus on randomised controlled trials (RCTs), to a level where they are able to contribute effectively as a statistician to the planning, conduct and reporting of a standard RCT.

Generic skills

Independent problem solving, critical appraisal of research literature, clarity of written expression, sound communication of technical concepts

Last updated: 24 August 2019