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This subject provides an in-depth look into the methods, algorithms and techniques behind biomolecular structure determination. In particular, students will be exposed to prominent techniques in the field for example: X-ray Crystallography, Nuclear Magnetic Resonance (NMR) and cryogenic-Electron Microscopy (cryo-EM). As part of a general introduction into measurement techniques students will visit state-of-the-art NMR, cryo-EM and X-ray facilities at the Bio21 Institute and the Australian Synchrotron. Using industry standard software packages, students will learn to input and handle data to reconstruct biomolecular structure and dynamics across the range of techniques. The computer based laboratories will be overseen by practitioners in the field. This multi-disciplinary subject is co-taught by staff in the School of Physics, Chemistry and Biomedical sciences. There is particular emphasis on integration of these disciplines with students receiving both theoretical and practical knowledge of fundamental and frontier research and development in biomolecular structure determination.
Intended learning outcomes
On completion of this subject the student should be able to:
- Explain the measurement principles used to perform bio-molecular structure determination.
- Demonstrate high level computer based skills that can be used to study a range of biomolecular structural problems in biology.
- Compare and contrast the strengths and weakness of each technique and explain how they can be applied to advance how these techniques may be applied both in advanced scientific research and biotechnology development.
- Understand and articulate advances in biomolecular imaging and structure determination.
- Ability to undertake problem identification, formulation and solution;
- Ability to utilise computer based systems to solve complex problems;
- Ability to manage information and documentation;
- Capacity for creativity and innovation;
- Ability to communicate effectively within an interdisciplinary environment.
Last updated: 8 November 2019