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This subject describes the molecular mechanisms underpinning eukaryotic cell organisation, morphology and behaviour and their importance in biomedicine. We will explore the relationships between cellular organisation and the biological functions of normal and stressed cells, as well experimental strategies for investigating the molecular basis of these relationships. The subject matter includes the compartmentalisation of eukaryotic cells; intracellular trafficking of biomolecules; the structure, function and biogenesis of subcellular organelles; protein folding and maturation; vesicle-mediated transport; structure and function of the extracellular matrix and cell adhesion molecules and their role in diseased states such as malignancies; cellular stress responses and linked signal transduction events; cytoskeletal structures and the signal transduction processes regulating the assembly and disassembly of actin-cytoskeleton; molecular processes determining cell movement and shape changes; imaging of processes within live cells.
Intended learning outcomes
On completion of this subject students should be able to:
- Explain the common principles that govern protein trafficking in eukaryotic cells
- Discuss mechanisms regulating cell adhesion, cell migration, and intracellular signalling pathways
- Propose experimental approaches to interrogate intracellular protein trafficking events, cell movement and intracellular signalling events
- Analyse and interpret imaging data using computer-based software
- Read, interpret and assess the current scientific literature on molecular cell biology.
- Discuss the design, choice, use and ethical considerations of model organisms and cell lines in molecular cell biology
On completion of this subject, students should have developed the following generic skills:
- The ability to analyse and interpret scientific literature and related resource materials.
- The capacity to develop ideas from theoretical principles to practical explanations.
- The capacity to integrate knowledge across disciplines.
- The ability to comprehend a question, evaluate the relevant information and communicate an answer.
Last updated: 24 January 2023