Downstream Bioprocessing (CHEN90035)
Graduate courseworkPoints: 12.5Not available in 2024
About this subject
Overview
| Fees | Look up fees |
|---|
AIMS
The goal of the course is to develop familiarity with the requirements and methods of downstream processing, i.e., separation, purification and formulation, in biotechnological applications, particularly for biopharmaceutical production. The course will introduce general principles of downstream processing but most of the semester will be devoted to the treatment of the most important unit operations employed in downstream processing. As is typical for chemical engineering courses, this one will include elements of both analysis and synthesis (i.e., design). Although the modern industry depended extensively on empiricism over much of its first few decades, there is increasing interest in and use of a deeper fundamental understanding of individual unit operations, including use of detailed computer simulations. The emphasis in the course will be on such a fundamental treatment of the various operations that we will encounter and will include use of computational models. References to relevant published research articles will also be provided.
INDICATIVE CONTENT
Biological products and impurities. Bioseparations strategies; Analytical methods; Cell lysis. Formation of solids: Flocculation, precipitation; Removal of solids: Centrifugation. Membrane processes: Filtration principles. Modes and of Optimisation of filtration. Chromatography: Overview and principles, operating modes, applications of chromatography for different biopharmaceutical products; Modelling of chromatographic behaviour; Viral clearance. Crystallisation; Drying; Additional topics in formulation.
Intended learning outcomes
On completion of this subject the student is expected to:
- Develop a familiarity with the requirements and methods of downstream processing to be able to differentiate the need for separation, purification or formulation operations in biotechnological applications.
- Students will be able to analyse downstream processing or separation requirements to design appropriate unit operations for the specific applications or processes.
- At the end of this subject students will be able to demonstrate the ability to use computational models to evaluate and design various unit operations in downstream processing.
Generic skills
- Capacity for independent thought
- Awareness of advanced technologies in the discipline
- Ability to apply knowledge of basic science and engineering fundamentals
- Ability to undertake problem identification, formulation and solution
- Ability to utilise a systems approach to design and operational performance
Last updated: 8 November 2024
Eligibility and requirements
Prerequisites
One of
| Code | Name | Teaching period | Credit Points |
|---|---|---|---|
| CHEN30016 | Momentum, Mass and Heat Transfer | Semester 2 (On Campus - Parkville) |
12.5 |
OR
One of
| Code | Name | Teaching period | Credit Points |
|---|---|---|---|
| CHEN30005 | Heat and Mass Transport Processes | No longer available |
(Prior to 2023)
OR
Admission into the MC-CHEMENG Master of Chemical Engineering, Chemical specialisation (formal) in the MC-ENG Master of Engineering
Corequisites
None
Non-allowed subjects
None
Inherent requirements (core participation requirements)
The University of Melbourne is committed to providing students with reasonable adjustments to assessment and participation under the Disability Standards for Education (2005), and the Assessment and Results Policy (MPF1326). Students are expected to meet the core participation requirements for their course. These can be viewed under Entry and Participation Requirements for the course outlines in the Handbook.
Further details on how to seek academic adjustments can be found on the Student Equity and Disability Support website: http://services.unimelb.edu.au/student-equity/home
Last updated: 8 November 2024
Assessment
| Description | Timing | Percentage |
|---|---|---|
Continuous assessment comprising regular homework problem sets (2 per week, for 4 weeks = 8 problem sets).
| From Week 1 to Week 4 | 10% |
One 1-hour mid-semester examination in week 2.
| Week 2 | 35% |
A computational project that applies the use of Chromatography Analysis and Design Toolkit (CADET) package.
| Week 3 | 20% |
One 1-hour end-of-semester examination in week 4.
| Week 4 | 35% |
Last updated: 8 November 2024
Dates & times
Not available in 2024
Time commitment details
200 hours
What do these dates mean
Visit this webpage to find out about these key dates, including how they impact on:
- Your tuition fees, academic transcript and statements.
- And for Commonwealth Supported students, your:
- Student Learning Entitlement. This applies to all students enrolled in a Commonwealth Supported Place (CSP).
Subjects withdrawn after the census date (including up to the ‘last day to withdraw without fail’) count toward the Student Learning Entitlement.
Last updated: 8 November 2024
Further information
- Texts
Prescribed texts
Chemical Product Development (1):
None
Biochemical Engineering (2):
M. Shuler and F. Kargi, Bioprocess Engineering, Second edition
The Literature and Culture of Australia (3):
Robert Hughes, The Fatal Shore: The Epic of Australia’s Founding. 1987
Nicholas Jose, ed. The Literature of Australia: An Anthology. 2009
Peter Carey, True History of the Kelly Gang: A Novel. 2000
Jill Ker Conway, The Road from Coorain. 1989
Doris Pilkington, Follow the Rabbit-Proof Fence. 1996
- Related Handbook entries
This subject contributes to the following:
Type Name Course Master of Chemical Engineering Specialisation (formal) Chemical with Business Specialisation (formal) Chemical Specialisation (formal) Biochemical - Available through the Community Access Program
About the Community Access Program (CAP)
This subject is available through the Community Access Program (also called Single Subject Studies) which allows you to enrol in single subjects offered by the University of Melbourne, without the commitment required to complete a whole degree.
Please note Single Subject Studies via Community Access Program is not available to student visa holders or applicants
Entry requirements including prerequisites may apply. Please refer to the CAP applications page for further information.
Additional information for this subject
Subject coordinator approval required
- Available to Study Abroad and/or Study Exchange Students
Last updated: 8 November 2024