Laboratory Models of Human Disease (BMSC90021)

Graduate courseworkPoints: 12.5On Campus (Parkville)

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Overview

Availability
Semester 1
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Personalized medicine is the end goal of advances in genomics. Many patients are now able to have their genome sequenced and many, many new human sequence variants are being discovered on a weekly basis. How can these data be analysed to benefit the patient? How can we interpret genomic data to determine if a sequence variant is likely to be pathological or be causative for a specific disease phenotype. This subject will provide students with experience of a pipeline that can be used to analyse genomic variants and a framework for decision-making about the types of laboratory studies that can be utilized to gain further information about a gene and related sequence variants.

Intended learning outcomes

On completion of this subject, students should be able to:

  • Analyse how genetic variants are identified in the clinic.
  • Synthesise ethical and patient-centred issues associated with genomic sequencing and evaluate strategies to address these.
  • Apply relevant technologies to investigate pathological genetic variation and interpret the data obtained from these analyses.
  • Design a workflow utilising a range of experimental techniques to analyse the function of genomic variants.
  • Evaluate various models available for analysis of gene and protein function.

Generic skills

  • The ability to work collaboratively and constructively in a multidisciplinary and multicultural team environment
  • Time management, self-regulation, project management and problem-solving skills
  • The ability to collect, analyse, interpret and critically evaluate authentic scientific data
  • The ability to communicate with varied audiences and stakeholders using appropriate written, oral and visual communication skills

Last updated: 4 March 2025

Eligibility and requirements

Prerequisites

None

Corequisites

None

Non-allowed subjects

None

Recommended background knowledge

Students should have completed an undergraduate degree in a biomedical science, bioengineering, or bioscience discipline.

Inherent requirements (core participation requirements)

The University of Melbourne is committed to providing students with reasonable adjustments to assessment and participation under the Disability Standards for Education (2005), and the Assessment and Results Policy (MPF1326). Students are expected to meet the core participation requirements for their course. These can be viewed under Entry and Participation Requirements for the course outlines in the Handbook.

Further details on how to seek academic adjustments can be found on the Student Equity and Disability Support website: http://services.unimelb.edu.au/student-equity/home

Last updated: 4 March 2025

Assessment

DescriptionTimingPercentage

Written assignment

  • 2500 words
From Week 6 to Week 850%

Multimedia presentation made up of an Oral presentation (10 minute talk + 5 minutes questions) and a written submission (approx. 1000 words equivalent)

  • 2500 words (equivalent)
During the examination period50%

Last updated: 4 March 2025

Dates & times

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  • Your tuition fees, academic transcript and statements.
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       -  Student Learning Entitlement. This applies to all students enrolled in a Commonwealth Supported Place (CSP).
     

    Subjects withdrawn after the census date (including up to the ‘last day to withdraw without fail’) count toward the Student Learning Entitlement.

Last updated: 4 March 2025

Further information

Last updated: 4 March 2025